The immune system can be modulated by vaccination, nutrition and herbal remedies, and it can be suppressed by poor nutrition, as well as some health conditions e.g. infectious diseases, metabolic/endocrine diseases and by old age. A number of essential nutrients are involved in immune function, and if these are deficient in the diet, immune function will be compromised. Immune-modulating malnutrition may not be obvious from looking at the outside of the horse, because it may involve shortages of essential microminerals not just shortage of all nutrients including energy and protein. Some plant materials are known to have immune modifying properties, and these may help the immune system to work effectively. Immunity is the specific resistance to disease and involves the production of a specific type of cell or molecule to destroy a particular foreign substance that has attacked the body. Sarcoids, immunity and nutrition Sarcoids are tumours of skin fibroblasts, which are described by experts as a type of skin cancer. They are not a true cancer because they usually stay strictly within the skin, but neither are they simply warts or suchlike. Any equine can be affected by sarcoids, including horses, ponies, donkeys and zebras. There is some genetic susceptibility, with some horses having a good resistance to them, and others being very susceptible to them. Exactly why horses develop sarcoids is not well understood. The tumours may spread – in some cases rapidly – across the horse. A number of different types have been identified, which have quite different appearances. If left untreated, they may become too extensive to treat or cause the horse distress such as large bleeding tumours that attract flies or affect vision. It’s possible that immune dysregulation is involved in sarcoid development, but this is an unexplored area. Some of the topical treatments have immune modifying properties, and a bio-immunotherapy treatment has been shown to have some success. Some owners have reported success with sarcoids disappearing or receding after a period of good health has followed a period of immunosuppression. Sarcoids are, however, still difficult to treat, and treatment may not be successful. A variety of treatments can be used, but none can be guaranteed. Ideally, the immune system attacks sarcoid-tumour-specfic antigens, and therefore kills the sarcoid. Despite the fact that a well-functioning immune system is not a guarantee of a sarcoid disappearing, it is likely that a compromised immune system could allow sarcoids to persist and/or spread.
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